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KMID : 0356620160310040598
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Journal of Korean Society of Endocrinology
2016 Volume.31 No. 4 p.598 ~ p.603
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Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
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Han Seung-Jin
Kim Kyung-Soo
Kim Won-Jin
Kim Jung-Hee
Lee Yong-Ho
Nam Ji-Sun
Seo Ji-A
Kim Bu-Kyung
Lee Ji-Hyun
Chung Jin-Ook
Kim Min-Hee
Sohn Tae-Seo
Choi Han-Seok
Hong Seong-Bin
Chung Yoon-Sok
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Abstract
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Background: The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.
Methods: Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.
Results: Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m2) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.
Conclusion: Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.
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KEYWORD
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Klinefelter syndrome, Obesity, Hyperglycemia
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